Signing protein-protein interaction networks.

ABSTRACT:

Motivation

Protein-protein interactions (PPIs) provide the skeleton for signaling pathways in the cell. Their experimental measurement, however, reveals only the existence of an interaction without any information on its functional roles. A key step in developing a working logical model of cell signaling is annotating activation/repression (sign) of an interaction.

Results

Here, we develop SIGN Annotation aLgorithm (SIGNAL), a method for annotating PPI networks with signs based on cause-effect data. The approach is based on a multiplicative model in which the effect of a pathway is assumed to be the product of the signs along its edges. The algorithm uses network propagation techniques to quantify the influence of each edge on gene expression changes, and the resulting featu

SUBMITTER: Signorini LF 

PROVIDER: S-EPMC12781092 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature