Enhancing the Osseointegration of Titanium Implants by Modulating M1/M2 Macrophage Polarization through PI3K-Akt Signal Pathway on a "Cortex-like" Microarc Oxidation Coating.

ABSTRACT: Surface modification of titanium implants to enhance osseointegration plays a crucial role in the success of titanium implant therapy; however, the underlying mechanisms remain unclear. This study systematically elucidates the mechanisms underlying osseointegration enhancement in titanium implants with "cortex-like" microarc oxidation (MAO) coatings through material characterization, in vivo and in vitro experiments, and bioinformatics analysis, revealing surface-modified titanium implants synergistically regulate immune response, angiogenesis, and osteogenesis during the process of osseointegration. The "cortex-like" MAO coating exhibits advantageous physicochemical properties, including hybrid micronano-morphology, superhydrophilicity, and stable phase construction. It induces an anti-in

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12781106 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature