Targeted Infection Control and Tissue Integration via pH-Sensitive Smart Coatings on Implant Surfaces.

ABSTRACT: A stimuli-responsive drug delivery coating is proposed for titanium (Ti) implants to locally treat infectious and peri-implant inflammatory diseases. The system integrates a pH-responsive film based on poly(methacrylic acid) (PMAA) film over a layer-by-layer (LbL) drug delivery platform containing tetracycline (TC) complexed with anionic beta cyclodextrin (βCD). This smart coating was designed to control drug release, maintain antimicrobial activity against biofilm-forming pathogens, and enhance soft tissue sealing at the implant interface. The coating effectively regulated drug release, exhibited favorable hydrophilicity, and reduced surface roughness compared with untreated Ti surfaces. Cytocompatibility was confirmed in both monolayer cell cultures and collagen matrix environments, with

SUBMITTER: Pereira MMA 

PROVIDER: S-EPMC12781112 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature