Was Motorized Spiral Enteroscopy Too Risky? A Systematic Review and Meta-Analysis Including German Registry Data.

ABSTRACT:

Background and study aims

Motorized spiral enteroscopy (MSE) was introduced as a major advancement in small-bowel enteroscopy, enabling higher complete enteroscopy rates with shorter procedure times. However, after a fatal adverse event (AE) involving severe esophageal injury, the device was withdrawn from the market in July 2023. This raised questions about whether earlier safety signals were missed.

Methods

We conducted a systematic review and meta-analysis comparing MSE with balloon-based enteroscopy (double-balloon [DBE] and single-balloon enteroscopy [SBE], analyzed together). Outcomes included overall AEs, serious AEs (SAEs), and data collection quality. Results from the German PowerSpiral Registry were included, comprising 647 MSE procedures in 523 patients (January 2

SUBMITTER: Steinbruck I 

PROVIDER: S-EPMC12781184 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature