Integrated Multi-Omic Analysis Identifies Altered Colonic Brush Border Profile as a Key Feature of Microscopic Colitis.

ABSTRACT:

Background

Microscopic colitis (MC), comprising lymphocytic colitis (LC) and collagenous colitis (CC), is an inflammatory bowel disease with increasing incidence. MC etiopathogenesis remains unknown; however, altered colonic epithelial integrity may underlie uncontrolled luminal antigen passage, triggering immuno-inflammatory responses.

Objective

The aim of this study was to further define the involvement of the colonic epithelium in MC.

Methods

A paired transcriptomic and proteomic analysis followed by epithelial ultrastructural examination was performed on colonic biopsies from LC and CC patients, and from irritable bowel syndrome with a predominance of diarrhoea (IBS-D) and healthy subjects (H) as control groups. The impact of budesonide therapy on the epithelial s

SUBMITTER: Guagnozzi D 

PROVIDER: S-EPMC12781189 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature