Prophylactic Incisional Negative Pressure wound therapy (NPWT) for major Amputations (PINTA): protocol for randomized controlled trial of single-use NPWT devices for closed-incision major lower extremity amputations.

ABSTRACT:

Background

Major lower extremity amputations are frequently performed for end-stage peripheral arterial disease and progressive diabetic foot complications. Wound complications after amputation affect up to one-third of limbs. The patient cohort undergoing amputation are typically high risk for poor wound healing, often with unmodifiable risk factors in an urgent clinical setting. Incisional negative pressure wound therapy (NPWT) has been shown to reduce wound complications in other high-risk populations. This randomized controlled trial investigates whether prophylactic NPWT reduces wound complications in patients after major amputation compared with standard dry dressings.

Methods

This protocol describes a prospective, multicentre, randomized controlled trial with an inter

SUBMITTER: Power Foley M 

PROVIDER: S-EPMC12781197 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature