Comparative effectiveness of preoperative localization techniques for non-palpable breast lesions: multicentre real-world study.

ABSTRACT:

Background

The increasing detection of non-palpable breast lesions has made accurate preoperative localization essential to optimize breast-conserving surgery. Although multiple localization methods exist, there is still a lack of robust, large-scale, multicentre evaluations comparing different techniques.

Methods

The LOCALIZATION01 study compares real-world data from 13 breast units in Italy and Switzerland on the impact of localization techniques on breast-conserving surgery for non-palpable lesions between 2016 and 2024. Four localization techniques were compared: wire-guided (WGL), radio-guided (ROLL), magnetic seed (MSL), and carbon (CL). The main outcomes were margin status, calculated resection ratio, postoperative complications, and surgical time. Subgroup analyses w

SUBMITTER: Corsi F 

PROVIDER: S-EPMC12781200 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature