The Effect of Comorbid Major Depressive Disorder on Working Memory in Young Adults With ADHD and the Mediating Role of the DLPFC.

ABSTRACT:

Background

Attention-Deficit/Hyperactivity Disorder (ADHD) and Major Depressive Disorder (MDD) both exhibit working memory (WM) impairments and frequently co-occur. However, the impact of comorbid MDD on WM in ADHD patients and the underlying mechanisms remain unclear.

Methods

The study included 409 adults, comprising 125 ADHD patients comorbid with MDD (ADHD+MDD), 145 ADHD patients without MDD (ADHD-MDD), and 139 healthy controls. In addition, functional connectivities (FCs) with the region of interest-the dorsolateral prefrontal cortex (DLPFC)-were analyzed in a subsample to explore the potential underlying neural mechanism.

Results

The WM scores of the ADHD+MDD group were higher than those of the ADHD-MDD group. In all ADHD patients, depression scores were positive

SUBMITTER: Lai QJ 

PROVIDER: S-EPMC12781219 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature