Influence of ventilatory settings on pendelluft and expiratory muscle activity in hypoxemic patients resuming spontaneous breathing.

ABSTRACT:

Background

Pendelluft and expiratory muscle activity during spontaneous breathing should be minimized to reduce potential harmful effects. This study aimed to describe pendelluft and expiratory muscle activity in hypoxemic patients recovering spontaneous breathing after ≥ 72 h of lung-protective, fully controlled mechanical ventilation (MV) and assess the effect of pressure support ventilation (PSV) and positive end-expiratory pressure (PEEP).

Methods

A physiological, randomized crossover study was conducted in hypoxemic patients receiving three levels of PSV: 5, 10, and 15 cmH₂O, and two PEEP levels: based on electrical impedance tomography before spontaneous breathing (PEEP_EIT) or according to PEEP-FiO₂ tables (PEEP_ARDS). Pendelluft was def

SUBMITTER: Cornejo RA 

PROVIDER: S-EPMC12781249 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature