A severe Clostridioides difficile ribotype 027 infection in Beijing, China, july 2024.

ABSTRACT:

Background

Clostridioides difficile ribotype (RT) 027 is particularly virulent, capable of causing severe conditions such as ileus, toxic megacolon, hypotension, or shock. Outbreaks of RT027 C. difficile are more frequently reported abroad compared to China.

Methods

We present a case of toxic megacolon caused by an RT027 C. difficile infection and trace the source of the infectious agent using whole genome sequencing. The agar dilution approach was utilized to determine antimicrobial susceptibility.

Results

Phylogenetic analysis demonstrated that the origin of this isolate was located in the same bifurcating branch of strains previously isolated in Beijing in 2012, yet it clusters within a new subcluster. The single nucleotide polymorphism (SNP) differences between th

SUBMITTER: Chen X 

PROVIDER: S-EPMC12781333 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature