NEO1 modulates the A1 astrocyte polarization in subarachnoid hemorrhage through the cPLA2-MAVS signaling pathway.

ABSTRACT: Neuroinflammation following subarachnoid hemorrhage (SAH) plays a critical role in multiple pathological pathways and poor prognosis. Several studies have indicated that resting astrocytes can polarize into at least two distinct phenotypes following SAH, pro-inflammatory A1 phenotype and anti-inflammatory A2 phenotype. However, the specific polarization patterns of astrocytes after SAH have not been fully elucidated. Targeting A1 astrocytes after SAH may represents a promising strategy for mitigating neuroinflammatory and enhancing neurological recovery. Our single-cell RNA sequencing revealed an increase in A1 astrocytes after SAH. Furthermore, the data suggested that NEO1 may be involved in astrocyte polarization. Then, we generated astrocyte-specific NEO1 conditional knockout (cKO) mice

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12781416 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature