Deciphering the personalized functional redundancy hierarchy in the gut microbiome.

ABSTRACT:

Background

Functional redundancy (FR) in the human gut microbiome is crucial for maintaining stability and resilience, exhibiting a hierarchical structure. However, the precise configuration and functional implications of this hierarchy remain elusive and limited by single-metric measurements. We aimed to develop a method that comprehensively characterizes the hierarchical organization of functional redundancy in personalized microbiomes.

Results

We represented functional redundancy as a network and developed a structural entropy (SE)-based approach to elucidate FR hierarchy, revealing functional redundancy clusters (FRCs)-groups of species capable of independently executing specific metabolic pathways. Through controlled simulations and cross-cohort analyses spanning 4912 g

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12781464 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature