Context-dependent MAN1A1 protein expression in metastatic breast cancer progression predicts patient survival.

ABSTRACT:

Background

Alterations in N-glycosylation are frequently observed in breast cancer metastasis but are not well understood. Recently, decreases in expression of the Golgi α-mannosidase I MAN1A1 have been linked to worse patient prognosis in breast cancer.

Methods

To examine MAN1A1 expression in breast cancer progression, we developed and conducted MAN1A1 immunostaining of breast cancer tissue microarrays (TMAs), which were analyzed using pathology-guided object classifiers, which identified normal breast epithelial cells, primary tumor cells, and metastatic tumor cells.

Results

MAN1A1 protein expression was significantly increased in primary tumor and local lymph node metastasis for a cohort of patients without distant metastases (N = 48). Changes in MAN1A1 protein exp

SUBMITTER: Jenkinson NM 

PROVIDER: S-EPMC12781482 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature