Comprehensive evaluation of the prevalent insulin resistance indices for pan-cancer incidence and mortality prediction.

ABSTRACT:

Background

Insulin resistance (IR) is increasingly recognized as a significant factor for cancer development and progression. While the triglyceride-glucose (TyG) index and its derivatives (TyG-BMI (body mass index), TyG-WC (waist circumference), and TyG-WHtR (waist-to-height ratio)) have been developed as reliable and straightforward surrogate tools for reflecting IR status, their comparative associations with pan-cancer incidence and mortality remain unclear. This study aimed to systematically evaluate the associations of these four IR-related indices with pan-cancer incidence and cancer-specific mortality in a large prospective cohort.

Methods

This prospective cohort study analyzed data from 333,297 participants in the UK Biobank. The four IR-related indices mentioned abo

SUBMITTER: Luo S 

PROVIDER: S-EPMC12781529 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature