Magnetically Retrievable Platinum Nanoreporters for Efficient Lateral Flow Immunoassay in Complex Bio-Samples.

ABSTRACT: Lateral flow immunoassays (LFIAs) are widely used for point-of-care diagnostics, but their development is challenged by the complexity and variability of patient samples. In particular, LFIAs often exhibit reduced sensitivity and specificity when used with patient samples, compared to their performance with analyte-spiked idealized matrices. Patient samples are inherently complex, with variations in physical and biochemical properties between patients. This complexity has consequences for the performance of LFIAs, and can result in non-specific binding on the test line, discoloration of the nitrocellulose membrane, and incomplete sample flow along the test strip. To address these challenges, a magnetically retrievable platinum nanoreporter (termed Pt@Fe₃O₄) is develop

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC12781628 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature