Direct thrombectomy versus bridging alteplase medicine in anterior circulation stroke following endovascular therapy: a multi-center cohort study.

ABSTRACT:

Objective

Intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) and endovascular therapy (EVT) are established treatments for acute ischemic stroke (AIS) due to large vessel occlusion (LVO) in the anterior circulation. This study aimed to compare the safety and efficacy of bridging therapy (rt-PA before EVT) versus direct EVT in a real-world, multicenter setting.

Methods

In this retrospective multicenter cohort study, 724 patients with anterior circulation AIS treated with EVT within 8 h of symptom onset were analyzed. Patients received either pre-EVT rt-PA (n = 314) or direct EVT without rt-PA (n = 410). Primary outcomes included 3-month functional independence (modified Rankin Scale (mRS) 0-2), excellent outcome (mRS 0-1), and mortality. Secondary

SUBMITTER: Zeng X 

PROVIDER: S-EPMC12781638 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature