Biological characteristics of an enterovirus A71 subgroup C4 strain isolated in China.

ABSTRACT:

Background

Hand, foot, and mouth disease (HFMD) is a widespread infectious disease primarily affecting infants and young children. Enterovirus A71 (EV-A71) comprises eight genogroups, among which subgroup C4 is the dominant viral agent in China and is frequently associated with HFMD and central nervous system infections. The genetic characteristics of an EV-A71 subgroup C4 strain obtained in this study were analyzed using whole-genome sequencing. Its biological characteristics, including infectivity, replication, and cytotoxicity, were investigated in human rhabdomyosarcoma (RD) and African green monkey kidney (Vero) cells.

Methods

A clinical EV-A71 C4 subgourp GD10 strain isolated in China was examined to evaluate its genetic and biological features. Its relationships with

SUBMITTER: Ma T 

PROVIDER: S-EPMC12781644 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature