Study on the heteroresistance of carbapenem-resistant Klebsiella pneumoniae to Tigecycline and Polymyxin B and antibacterial activity of combined drugs in vitro.

ABSTRACT:

Background

Antimicrobial resistance is a global concern. Tigecycline (TGC) and polymyxin B (PMB) constitute some of the last treatment options remaining for carbapenem-resistant Klebsiella pneumoniae (CRKP). However, heteroresistance to these two drugs has rarely been reported. In this study, we investigated the prevalence of heteroresistance to TGC and PMB among clinically isolated CRKP strains, and assessed the synergistic activity of TGC plus PMB, TGC plus imipenem (IPM), and PMB plus IPM against heteroresistant CRKP.

Methods

A total of 90 nonduplicated CRKP clinical isolates were collected from Tianjin Medical University General Hospital, China,from January 2022 to October 2022. PCR was used to detect the resistance genes. Population analysis profile (PAP) was performed

SUBMITTER: Dong Y 

PROVIDER: S-EPMC12781645 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature