Effects of chronic allergic lung inflammation on gut microbiota and depression-like behavior in mice.

ABSTRACT:

Aim

Emerging epidemiological studies have reported a link between allergic diseases, including asthma, and depression. Evidently, the gut microbiota is involved in the pathogenesis of asthma and depression. Therefore, we investigated whether allergic lung inflammation in mice causes gut microbial dysbiosis, via the gut-brain axis, which is potentially associated with depression.

Methods

Wild-type C57BL/6J female mice were sensitized with intranasal house dust mite (HDM) antigen or phosphate-buffered saline (PBS) for 6 weeks to induce chronic allergic lung inflammation. Sucrose preference tests were performed for assessing depression. Fecal samples were collected, and 16S ribosomal RNA gene sequencing was performed to detect differences in gut microbiota composition between t

SUBMITTER: Kanaya A 

PROVIDER: S-EPMC12781662 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature