Metabolomic biomarkers predict long-term physical function in survivors of acute respiratory failure.

ABSTRACT:

Introduction

Acute respiratory failure (ARF) often leads to post-intensive care syndrome, including persistent physical impairments after ICU discharge. Emerging evidence suggests that mitochondrial bioenergetic dysfunction, detectable through metabolomic profiling, may contribute to poor recovery.

Methods

We performed a retrospective study comprising of untargeted metabolomic profiling using ultrahigh performance liquid chromatography-mass spectrometry (UHPLC-MS) on serial serum samples from 70 ARF patients taken at ICU admission, during hospitalization and at discharge. Physical function was assessed post-discharge using the Short Physical Performance Battery (SPPB). Correlation and logistic regression analyses were performed to identify metabolomic predictors of six-month

SUBMITTER: Haastrup AI 

PROVIDER: S-EPMC12781719 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature