The lncRNA PARylator promotes PARP1 activation and resistance to DNA‑damaging therapy in esophageal squamous cell carcinoma.

ABSTRACT:

Background

Outcomes for patients with esophageal squamous cell carcinoma (ESCC) remain poor, partly due to treatment resistance, particularly to DNA-damaging therapies. Poly(ADP‑ribose) polymerase 1 (PARP1) plays a critical role in repairing single‑strand DNA breaks (SSBs). Unrepaired SSBs can be converted into double‑strand breaks (DSBs) during DNA replication, potentially leading to cell death. Genomic amplification of the distal portion of chromosome 3q (3q26-q29) is a frequent copy‑number alteration in ESCC, which harbors genes encoding several oncoproteins. However, whether long noncoding RNAs (lncRNAs) from this region contribute to ESCC pathogenesis and treatment resistance remains poorly understood.

Methods

In situ hybridization and qPCR were used to assess RNA expre

SUBMITTER: Qi TF 

PROVIDER: S-EPMC12781723 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature