MPP7 inhibits tumor metastasis through promoting snail degradation in clear cell renal cell carcinoma.

ABSTRACT:

Background

Tumor metastasis is a major factor of high recurrence and mortality in clear cell renal cell carcinoma (ccRCC), but its underlying mechanism remains elusive. This study focuses on investigating the impact and underlying molecular mechanisms of MAGUK p55 subfamily member 7 (MPP7) on the metastasis of ccRCC.

Methods

The clinical significance of MPP7 in patients with ccRCC was investigated based on The Cancer Genome Atlas (TCGA), Genotype Tissue Expression Project (GTEx) databases and clinical tissue samples. Slow aggregation, microscopic photography and immunofluorescence (IF) assay were applied to assess the effect of MPP7 on intercellular adhesion, cell morphology, and cytoskeletal F-actin, respectively. Transwell and wound-healing assays were used to detect cell

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12781724 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature