Tetrahydromagnolol targets TRIM38 to mediate PANoptosis in cancer cells and has the potential for synergistic cancer therapy.

ABSTRACT:

Background

Tetrahydromagnolol (THM) is a compound isolated from Magnolia officinalis with unique chemical structure and composition. However, its anticancer effect of THM and the underlying molecular mechanisms remain unclear.

Method

Firstly, the anticancer effects of THM on different cancer cell lines in vitro were investigated. Subsequently, the antitumor activity of THM was further evaluated in vivo and in vitro using colorectal and lung cancer models. This assessment involved the effects of THM on cell viability, apoptosis, proliferation, cell cycle progression, and tumor growth inhibition. In addition, the anticancer molecular mechanisms of THM were determined by RNA sequencing, western blot, immunohistochemistry, immunofluorescence, CETSA, and SPR. Meanwhile, the effec

SUBMITTER: Gu X 

PROVIDER: S-EPMC12781742 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature