Ferulic acid in combination with ginsenoside Rb1 alleviates myocardial no-reflow by inhibiting platelet HMGB1 release and NET formation.

ABSTRACT:

Background

The no-reflow (NR) phenomenon remains a challenge in the treatment of acute myocardial infarction. This study aimed to explore the therapeutic potential and underlying mechanism of a combination of ferulic acid (FA) and ginsenoside Rb1 (Rb1), active components of the traditional Chinese herbal pair of Ligusticum chuanxiong Hort. and Panax ginseng C. A. Mey., respectively, in alleviating myocardial ischemia-reperfusion injury (MIRI) and NR.

Methods

A rat model of MIRI was established to evaluate the effects of FA and Rb1 on cardiac function, infarction/NR area, microthrombi formation, and serum biomarkers. An integrated strategy combining network pharmacology, molecular docking, and molecular dynamics simulations was employed to predict key pathways and targets. Pl

SUBMITTER: Li J 

PROVIDER: S-EPMC12781747 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature