Prognostic impact of Fusobacterium nucleatum in head and neck cancers: a meta-analysis of critical oncological outcomes.

ABSTRACT:

Background

It's a well-established fact that Fusobacterium nucleatum has been implicated in the pathogenesis and prognosis of several malignancies, but its role in head and neck cancers remains unclear. This systematic review and meta-analysis aimed to synthesize the evidence on the prognostic impact of Fusobacterium abundance in head and neck squamous cell carcinoma (HNSCC).

Methods

A comprehensive literature search of PubMed/MEDLINE, Web of Science, Scopus, and Embase was performed from inception to January 1, 2000, to October 15, 2025. Studies evaluating the association between Fusobacterium and oncological outcomes in HNSCC were included. Hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS) and disease-specific survival (DSS) were pooled usin

SUBMITTER: Bayrak AF 

PROVIDER: S-EPMC12781759 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature