Outcomes after biologic initiation among patients with severe asthma and normal lung function in the CHRONICLE study.

ABSTRACT: A subset of patients with severe asthma (SA) has normal lung function, defined by a pre-bronchodilator (BD) forced expiratory volume in 1 second (FEV₁) of ≥80% of predicted normal value. The effect of biologic treatments on patients with SA and normal lung function is not well understood. This analysis assessed the effectiveness of biologics among adults with SA and normal lung function using data from CHRONICLE (NCT03373045), a real-world observational study of United States patients with SA. Among the 233 patients in this analysis, 28.8% (n=67) had normal lung function, whereas 71.2% (n=166) had reduced lung function (pre-BD FEV₁ <80% of predicted normal). In the 12 months before initiating biologic treatment, annualized exacerbation rates were 1.19 (95% confidence

SUBMITTER: Panettieri RA 

PROVIDER: S-EPMC12781776 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature