Sleep and physical activity trade-offs and dementia risk: a prospective cohort study in UK Biobank participants.

ABSTRACT:

Background

Engaging in regular physical activity and obtaining recommended amounts of sleep are touted as strategies to promote healthy brain aging. However, as each day is only 24 h long, changing time spent in one activity must come at the expense or gain of another, making it necessary to understand how the whole 24-h activity composition is associated with dementia risk. We investigated the effect of substituting sleep duration for different levels of physical activity (i.e., inactivity, light activity, and moderate to vigorous physical activity; MVPA) in short sleepers (< 6 h) and normal sleepers (≥ 6 h and ≤ 9 h).

Methods

The study sample comprised 87,490 participants from the community-based UK Biobank, with 24-h behaviors estimated using up to 7 days of accelerometry

SUBMITTER: Yiallourou S 

PROVIDER: S-EPMC12781825 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature