A mechanism for telomere-specific telomere length regulation.

ABSTRACT: Telomere length is a critical determinant of telomere function and hence chromosome stability. Critically short telomeres induce cellular senescence and division arrest, which eventually may lead to devastating age-related degenerative diseases. Conversely, maintenance of telomere length is a hallmark of cancer. How telomere set-length is established and molecular mechanisms for telomere-specific length regulation remained unknown. Here, we detail a mechanism of a telomere-specific set-length regulation that causes important differences in telomere length between individual telomeres in the same cell. Indeed, the results show that telomerase recruitment is modulated in cis in a telomere-specific way. Increased Sir4 abundance on yeast TEL03L subtelomeric heterochromatin leads to a set-lengt

SUBMITTER: Teplitz GM 

PROVIDER: S-EPMC12781880 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature