Co-transcriptional splicing changes combine with reduced productive transcription initiation for cold-induced repression of FLC.

ABSTRACT: The Arabidopsis floral repressor locus FLC is epigenetically silenced during winter cold to align flowering with spring. During weeks of cold exposure, FLC transcription is progressively reduced both by transcriptional repression mediated by FLC antisense transcription and epigenetic silencing implemented through a Polycomb-mediated epigenetic switch. In the warm, FLC is transcriptionally repressed by coordinated changes in transcription initiation and RNA PolII speed in a mechanism involving proximal termination. Whether similar mechanisms contribute to the cold-induced FLC transcriptional repression is unknown. Here, we combine mathematical modelling and transcription profiling to investigate FLC transcriptional changes during the cold. We find different dynamics of spliced and unspliced

SUBMITTER: Maple R 

PROVIDER: S-EPMC12781886 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature