SFTSV-encoded microRNA-like small RNA as prognostic biomarkers in severe fever with thrombocytopenia syndrome.

ABSTRACT: Severe fever with thrombocytopenia syndrome (SFTS) is a highly fatal infectious disease caused by the SFTS virus (SFTSV). Reliable prognostic biomarkers are essential for early intervention, yet specific markers for SFTSV infection remain unidentified. In this study, we identified SFTSV-encoded microRNA-like small RNAs (milRNAs) in patients' sera and evaluated their potential as prognosis biomarker. A multi-phase study involving 170 laboratory-confirmed SFTS patients, 40 patients with other infection and 80 healthy controls was conducted. Small RNA deep sequencing was performed, followed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and TA cloning for individual validation. The expression dynamics of identified milRNAs were analyzed across different disease stage

SUBMITTER: Hu X 

PROVIDER: S-EPMC12781947 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature