Hippocampal subfield activity in schizophrenia: Effects of the disease course.

ABSTRACT: Alterations in hippocampal structure and function are established in schizophrenia. However, the specific patterns of hippocampal activity along the schizophrenia course remain unknown. Eighty-five study participants [34 schizophrenia probands (SZ), 32 first-degree relatives (REL), 19 healthy controls (HC)] underwent 3Tesla ultra-high resolution brain MRI (Vascular Space Occupancy); relative cerebral blood volume (rCBV)-an index of regional activity-was estimated across hippocampal subfields: dentate gyrus (DG), CA3, CA1, and subiculum (SUB). To examine effects of the schizophrenia course, SZ were stratified into SZ-Early (≤7 yrs. from psychosis onset), SZ-Mid-Course (8-14 yrs) and SZ-Advanced (≥15 yrs). REL were grouped into those with (RELP) and without (REL-NP) psychosis spectrum disord

SUBMITTER: Ivleva EI 

PROVIDER: S-EPMC12781969 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature