Characterizing amyloid and tau positron emission tomography-based stages across the clinical continuum.

ABSTRACT:

Introduction

We standardized positron emission tomography (PET) data across multiple cohorts and tracers to characterize the frequency of amyloid and tau PET severity along the clinical continuum.

Methods

Clinical stage was defined using cohort-specific criteria and included cognitively unimpaired (CU), mild cognitive impairment (MCI), and dementia. Amyloid severity was staged using Centiloids (CL). Tau severity was staged using a hierarchical Braak-based schema. The cumulative probabilities of PET-based stages were estimated using ordinal logistic regressions.

Results

Among 10,396 individuals (mean [standard deviation] age: 71.9 [7.1] years), amyloid levels ≥ 25 CL increased with age among CU and MCI, while amyloid levels ≥ 100 CL were most common in dementia. In 329

SUBMITTER: Cody KA 

PROVIDER: S-EPMC12782155 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature