Medium-chain triglycerides improve cognition and systemic metabolism in mouse models of Alzheimer's disease.

ABSTRACT: Lifestyle-based interventions, including dietary modifications, can reduce dementia risk. In this regard, dietary supplementation with medium-chain triglycerides (MCT) has shown potential therapeutic benefits in individuals with Alzheimer's disease. These effects are widely presumed to be mediated by hepatic conversion of MCT into circulating ketones. However, the physiological and cellular mechanisms underlying the benefits of MCT remain understudied, particularly in the context of Alzheimer's disease. Here, we investigated the cellular and molecular changes occurring in the brain and systemically in response to dietary supplementation with MCT versus a ketogenic diet. The experimental design consisted of comparing a 70% carbohydrate control diet to either a control diet supplemented with

SUBMITTER: M'Bra PEH 

PROVIDER: S-EPMC12782165 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature