White matter signals reflect information transmission between brain regions during seizures.

ABSTRACT: The white matter of the brain is a dynamic and active tissue that coordinates brain function through the transmission and modulation of information between regions via action potentials. Although scientific and clinical interest in studying white matter via diffusion imaging has grown rapidly, an electrophysiological understanding of white matter in healthy and disease states remains elusive. And although human white matter recordings are acquired in intracranial EEG studies in epilepsy, clinical evaluation typically focuses on grey matter structures to understand seizure generation and plan surgical intervention despite the role of white matter in coordinating and propagating epileptic activity. Here, we study white matter recordings in 29 patients with drug-resistant epilepsy who underwe

SUBMITTER: Revell AY 

PROVIDER: S-EPMC12782170 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature