Brief Report: Prenatal Antiretroviral Exposure and Concomitant Neurodevelopmental Problems Among 5-Year-Old Children Who Are HIV-Exposed and Uninfected.

ABSTRACT:

Background

Atazanavir (ATV) has been a preferred protease inhibitor prescribed to pregnant women with HIV, often given with tenofovir disoproxil fumarate (TDF)/emtricitabine. Studies have reported associations of prenatal exposure to ATV with early neurodevelopmental problems among children HIV exposed but uninfected (CHEU).

Setting

Prospective US-based multisite cohort study of CHEU.

Methods

Monolingual English-speaking CHEU from the Surveillance Monitoring for ART Toxicities study were evaluated for cognition, language, and behavior at age 5 years. Exploratory factor analyses using 10 composite scores were performed to estimate underlying factors reflecting covariation of these domains. Mean differences of standardized factor scores were compared between CHEU expose

SUBMITTER: Yao TJ 

PROVIDER: S-EPMC12782211 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature