Does Missing Medication Acutely Change Seizure Risk? A Prospective Study.

ABSTRACT:

Objective

The objective of this study was to determine whether missing individual doses of anti-seizure medications (ASMs) elevate short-term seizure risk in people with drug-resistant epilepsy.

Methods

In a prospective, community-based cohort, adults with drug-resistant epilepsy (≥ 3 seizures/month) or their caregivers recorded seizures and ASM intake with smartphone applications for 10 months each. Individual level analysis modeled the relationships between ASM adherence with seizure occurrence, as well as with a simplified seizure forecast via a 90-day moving average ("Napkin method"). Group-level analysis with a mixed-effects model was performed to examine the relationship between ASM adherence and simplified forecasts, while controlling for differences in individual sei

SUBMITTER: Goldenholz DM 

PROVIDER: S-EPMC12782288 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature