Reflex somatic testing for the detection of FGFR alterations in urinary tract carcinomas: A dual-institutional experience.

ABSTRACT:

Objective

To describe the prevalence and clinicopathologic associations of FGFR-altered urinary tract carcinomas in institutions incorporating reflex testing.

Methods

Next-generation sequencing was prospectively performed on urinary tract carcinomas for the detection of FGFR1-4 alterations at 2 tertiary care centers (2021-2025), using the Oncomine Comprehensive Assay (OCA) v3 DNA and OCA Plus RNA. Reflex testing was conducted on metastatic and/or advanced (pT3/4) carcinomas.

Results

The cohort included 366 patients (239 lower tract carcinomas, 72 upper tract carcinomas, and 55 metastases). Median age was 72.5 years (range, 36-97). Fifty-nine (16.1%) tumors were FGFR-altered. Forty-nine (13.4%) patients with actionable FGFR alterations (33 FGFR3 mutations, 13 FGFR3 fus

SUBMITTER: Nguyen NJ 

PROVIDER: S-EPMC12782305 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature