Using dried blood spots to estimate Toxoplasma gondii seroprevalence in pregnant women in Catalonia, Spain, and to serologically diagnose congenital toxoplasmosis.

ABSTRACT: Recent data on toxoplasmosis seroprevalence in Spain is limited, and pregnancy-screening programs are being discontinued. This study aimed to describe seroprevalence in pregnant women in Catalonia using newborn dried blood samples (DBS) from the Catalonian Newborn Screening (NBS) Program; as well as to assess detection of Toxoplasma gondii antibodies in DBS (Anti-Toxoplasma gondii ELISA (IgG/IgM), Euroimmun Lubeck, Germany) as a NBS tool and for retrospective diagnosis of congenital toxoplasmosis (CT) in cases from the Spanish Research Network of Congenital Toxoplasmosis (REIV-TOXO). A total of 3,231 DBS samples from NBS program (September 2022-August 2023) were randomly selected and analyzed, alongside with 30 DBS from CT confirmed cases. The overall seroprevalence of T. gondii IgG in pre

SUBMITTER: Guarch-Ibanez B 

PROVIDER: S-EPMC12782418 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature