MicroRNAs profiling in malaria and arbovirus coinfection: A systematic review protocol.

ABSTRACT:

Background

Coinfections between malaria and arboviruses such as Dengue virus (DENV), chikungunya Virus (CHIKV), and Zika virus (ZIKV) represent a significant clinical and public health challenge. The molecular pathogenesis of these coinfections is complex and poorly understood. MicroRNAs (miRNAs) are key regulators of gene expression and play a crucial role in the host response to infection. A comprehensive profile of miRNAs implicated in malaria-arbovirus coinfection could provide novel insights into disease mechanisms and reveal new targets for improved management and therapeutic strategies.

Methods

The review will be conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search strategy will be

SUBMITTER: Deutou Wondeu AL 

PROVIDER: S-EPMC12782442 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature