Exposure to Acetaminophen (Paracetamol) during Pregnancy and Childhood Cancer: A Population-Based Cohort Study in Taiwan.

ABSTRACT:

Background

The safety of using acetaminophen (paracetamol) during pregnancy has been questioned because of concerns about its potential negative impact on fetal development and the risk of adverse pediatric outcomes. We aimed to investigate whether maternal prescriptions of acetaminophen during pregnancy are associated with childhood cancer.

Methods

We conducted a population-based cohort study in Taiwan using data from the Maternal and Child Health Database linked to additional registries to identify children diagnosed with cancer between 2004 and 2017. Cox proportional hazard models were used to estimate effects. Probabilistic bias analysis was conducted to address potential biases and validate our findings.

Results

The cohort consisted of 2,269,384 mother-child pair

SUBMITTER: Sirirungreung A 

PROVIDER: S-EPMC12782464 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature