Environmental Factors and Risk of Early-Onset Dementia: A Population-Based Case-Control Study.

ABSTRACT:

Introduction

Dementia with symptom onset before the age of 65 is referred to as early-onset dementia (EOD). Many gaps exist regarding EOD etiology, including the role of environmental factors.

Methods

We conducted a population-based case-control study in Modena province, Northern Italy, enrolling and geocoding 326 EOD cases and 1,941 sex- and age-matched controls, to investigate the association of traffic-related benzene, green spaces around the place of residence, and exposure to artificial outdoor light at night (LAN). We used nonlinear modeling to assess the relation between environmental variables and disease risk, overall, and separately for Alzheimer's dementia (AD) and non-AD.

Results

Green spaces generally showed an inverse association with EOD risk that was a

SUBMITTER: Soncini C 

PROVIDER: S-EPMC12782616 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature