Individualizing Dual Antiplatelet Therapy (DAPT) Duration Based on Bleeding Risk, Ischemic Risk, or Both: An Analysis From the DAPT Study.

ABSTRACT:

Background

Guidelines recommend individualization of dual antiplatelet therapy (DAPT) duration. Whether to guide decisions based on bleeding risk, ischemic risk or a combination is not known.

Aims

To compare a bleeding prediction model, an ischemic prediction model, and the DAPT score in guiding DAPT duration.

Methods

11,648 patients in the DAPT Study were categorized into higher and lower risk using a bleeding model, an ischemic model, and the DAPT score. Effect of 30 vs. 12 months of DAPT on bleeding events, ischemic events, and the combination (net-adverse clinical events [NACE]) was assessed.

Results

Among patients stratified with the bleeding model, 30 vs. 12 months of DAPT resulted in similar ischemic and bleeding event rates. With the ischemic model, how

SUBMITTER: Mihatov N 

PROVIDER: S-EPMC12782624 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature