The Effectiveness of a Hospital-Based Antimicrobial Stewardship Program: A Three-Year Observational Study.

ABSTRACT:

Objective

The aim of the study was to evaluate the impact of a policy-driven Antimicrobial Stewardship Program (AMSP) on antibiotic consumption, prescribing compliance, infection control, resistance trends, and clinical outcomes in a tertiary care hospital in India over a 3-year period.

Subject and methods

A retrospective cross-sectional study compared pre-AMS (nurse-led) and post-AMS (multidisciplinary) phases (2022-2025). Indicators included antibiotic use, defined daily doses (DDD), days of therapy (DOT), policy compliance, resistance rates, and clinical outcomes. Statistical significance was set at p < 0.05.

Results

Overall antibiotic use decreased, with DDD/1,000 patient-days declining from 2,599.3 to 2,413.3 with p = 0.974>0.05 and DOT from 1,474.4 to 1,394.6 wi

SUBMITTER: Guchhait P 

PROVIDER: S-EPMC12782634 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature