Remote loading of an autoantigen in PLGA nanoparticles for the treatment of multiple sclerosis.

ABSTRACT: Autoimmune diseases like multiple sclerosis (MS) affect millions of people worldwide and have been growing in prevalence. Current therapeutic strategies either entirely suppress immune function or only offer modest efficacy. Research efforts have shifted focus more recently to antigen-specific therapies to promote immune tolerance and avoid compromising general immune function. Here, we show the application of a novel aqueous remote loading method using poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) to load myelin oligodendrocyte glycoprotein (MOG) peptide at high loading and encapsulation efficiency. MOG is a target of autoreactive T cells in MS. These NPs (750 ± 200 nm and - 16.7 ± 0.4 mV zeta potential) slowly and continuously released MOG peptide and decreased costimulatory mol

SUBMITTER: Din C 

PROVIDER: S-EPMC12782757 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature