Depressive Symptoms Correlate With Tau Accumulation Rates in Amyloid Positive Adults.

ABSTRACT:

Objective

Depression in Alzheimer's disease (AD) is linked to faster cognitive decline and increased tau pathology. This study examines the relationship between depressive symptoms and tau accumulation rates in older adults from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database.

Methods

Three-hundred and three ADNI participants with normal cognition, mild cognitive impairment, or dementia underwent serial [18F]-flortaucipir tau positron-emission tomography (PET) between 2015 and 2022. We assessed whether the Geriatric Depression Scale (GDS) score between baseline and final PET scans correlated with rates of tau accumulation in a temporal lobe meta-region of interest.

Results

GDS score was positively correlated with annualized tau accumulation rates in mo

SUBMITTER: Talmasov D 

PROVIDER: S-EPMC12782759 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature