The hepcidin-ferroportin axis modulates liver endothelial cell BMP expression to influence iron homeostasis in mice.

ABSTRACT:

Abstract

The liver hormone hepcidin regulates systemic iron homeostasis to provide enough iron for vital processes while limiting toxicity. Hepcidin acts by degrading its receptor ferroportin (encoded by Slc40a1) to decrease iron export to plasma. Iron controls hepcidin production in part by inducing liver endothelial cells (LECs) to produce bone morphogenetic proteins (BMPs) that activate hepcidin transcription in hepatocytes. Here, we used in vitro and in vivo models to investigate whether ferroportin contributes to LEC intracellular iron content to modulate BMP expression and, thereby, hepcidin. Quantitative proteomics of LECs from mice fed different iron diets demonstrated an inverse relationship between dietary iron and endothelial ferroportin expression. Slc40a1 knockdown pri

SUBMITTER: Fisher AL 

PROVIDER: S-EPMC12782961 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature