NK cells with adhesion defects and reduced cytotoxic functions are associated with a poor prognosis in multiple myeloma.

ABSTRACT:

Abstract

The promising results obtained with immunotherapeutic approaches for multiple myeloma (MM) call for a better stratification of patients based on immune components. The most pressing being cytotoxic lymphocytes such as natural killer (NK) cells that are mandatory for MM surveillance and therapy. Here, we performed a single-cell RNA sequencing analysis of NK cells from 10 patients with MM and 10 age/sex-matched healthy donors that revealed important transcriptomic changes in the NK cell landscape affecting both the bone marrow (BM) and peripheral blood compartment. The frequency of mature cytotoxic CD56dim NK cell subsets was reduced in patients with MM at the advantage of late-stage NK cell subsets expressing NF-κB and interferon-I inflammatory signatures. These NK cell sub

SUBMITTER: Blanquart E 

PROVIDER: S-EPMC12782982 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature