Single-cell and clonal analysis of AL amyloidosis plasma cells and their bone marrow microenvironment.

ABSTRACT:

Abstract

AL amyloidosis is a disorder characterized by expansion of clonal plasma cells in the bone marrow and distant end organ damage mediated by misfolded immunoglobulin free light chains. There are currently limited data regarding the functional characteristics of AL amyloidosis plasma cells and their surrounding bone marrow microenvironment. We performed 5' single-cell RNA sequencing on newly diagnosed, treatment-naïve patients with AL amyloidosis and healthy subjects. We identified generalized suppression of normal bone marrow hematopoiesis with distinct expansion of monocytes and subsets of CD4+ T cells in patients with AL amyloidosis. We detected significant transcriptional changes broadly occurring among immune cells with increased tumor necrosis factor-α signaling and int

SUBMITTER: Gort-Freitas NA 

PROVIDER: S-EPMC12782983 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature