Abnormal cortical topographic patterns associated with auditory verbal hallucination in first-episode schizophrenia.

ABSTRACT: Convergent phenomenological and neuroimaging evidence support that the dysregulated segregation and integration between brain networks have been implicated in the neural mechanism of auditory verbal hallucination (AVH) in schizophrenia. Nevertheless, the macroscale topographical alterations of functional networks in patients with AVH remain elusive. Cortical gradient mapping provides a novel approach to characterize the distribution pattern of functional organization in a multidimensional connectivity space. Here, leveraging resting-state functional MRI data from 104 first-episode drug-naïve schizophrenia (64 with AVH, 40 without AVH) and 90 matched healthy controls (HC), we extracted intrinsic connectivity gradients and measured the range of each gradient, manifold eccentricity, global, w

SUBMITTER: Gao Z 

PROVIDER: S-EPMC12783108 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature