Volumetric absorptive microsampling for lumateperone analysis: method validation and stability evaluation.

ABSTRACT: Lumateperone is a recently approved atypical antipsychotic for the treatment of schizophrenia, with moderate adverse effects. However, the risk of toxicity, mainly due to possible multidrug coadministration, makes the therapeutic drug monitoring (TDM) approach crucial for developing personalised therapies and reducing side effects. In the TDM research field, microsampling represents an innovative and effective approach based on the collection and analysis of small sample volumes (< 100 μL), exhibiting many advantages (such as enhanced analyte stability, minimally invasive procedures and simplified sample storage and transport) and improving patient adherence. For the first time, an analytical methodology based on microsampling was developed and fully validated for the analysis of lumateper

SUBMITTER: Milandri E 

PROVIDER: S-EPMC12783156 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature